MPP8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-560-479	Proteintech Group Inc 167961AP150UL	150 μL

Description

Heterochromatin component that specifically recognizes and binds methylated ′Lys-9′ of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression. Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression.

Specifications

• Antigen: MPP8
• Applications: Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: G3V8T1, Q3TYA6, Q99549
• Gene ID (Entrez): 290270, 54737, 75339
• Immunogen: MPP8 Fusion Protein Ag10268
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: MPHOSPH8

• Concentration: 0.31 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: HSMPP8, M phase phosphoprotein 8, MPHOSPH8, MPP8, TWA3
• Gene Symbols: Mphosph8
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody