Invitrogen™ mPR alpha Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA561376

Catalog No. PIPA561376

Description

Immunogen sequence: MAMAQKLSHL LPSLRQVIQE PQLSLQPEPV FTVDRAEVPP LFWKPYIYAG YRPLHQTWRF YFRTLFQQHN EA Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 81%.

The steroid progesterone induces the resumption of maturation in oocytes via a nongenomic pathway through binding to a novel, membrane progestin receptor (mPR). This pathway inhibits adenylyl cyclase and reduces intracellular cAMP, and also activates mitogen-activated protein kinase to effect signal transduction pathways. Three distinct groups, designated α, β and γ, comprise this gene family. mPRα, also designated progestin and adipoQ receptor family member VII (PAQR7), consists of an extracellular N-terminus, an intracellular C-terminus, and seven transmembrane domains. It is expressed in ovary, testis, placenta, uterus and bladder. mPRβ, also designated progestin and adipoQ receptor family member VIII (PAQR8), consists of eight putative transmembrane regions and an intracellular N-terminus that contains a leucine-rich motif. It is a 354 amino acid protein with a molecular mass of about 40 kDa and is expressed in brain and spinal cord. Both mPRα and mPRβ may be G protein-coupled receptors and may be involved in oocyte maturation.

Specifications

• Antigen: mPR alpha
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PAQR7
• Gene Alias: 2310021M12Rik; AV001994; BB007237; Membrane progesterone P4 receptor alpha; Membrane progesterone receptor alpha; Membrane progestin receptor alpha; mPR; mPR alpha; Mpra; MRPA; mSR; PAQR7; Pglp; PPAR-gamma-induced liver protein; Progesterone and adipoQ receptor family member 7; Progestin and adipoQ receptor family member 7; progestin and adipoQ receptor family member VII
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 164091
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q86WK9
• Gene Symbols: PAQR7
• Immunogen: Recombinant protein corresponding to Human mPR alpha. Recombinant protein control fragment (Product #RP-99833).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG