Invitrogen™ MPZ Monoclonal Antibody (C13), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA551126

Catalog No. FEMA551126

Description

Zero, also known as myelin protein zero (MPZ) is a Type 1 integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath in order to ensure stable synaptic transmission. Zero protein encompasses approximately 50% of total protein in the sheath scaffolding in contribution to structural integrity of peripheral myelin. Zero guides the compact myelin wrapping process through glycine zipper packing interface-dependent dimer and tetramer formation. Mutations (e.g. G134R) can abrogate multimer formation, cause demyelinating neuropathies, and are known to contribute to conditions that include Charcot-Marie-Tooth disease. Zero cytoplasmic domain undergoes serine and tyrosine phosphorylation, which appears to be prevalent during peak nerve myelination. Zero transcript is moderate in brain, abundant in thymus and most abundant in white matter of the CNS.

Specifications

• Antigen: MPZ
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% Proclin 300; pH 7.4
• Gene Accession No.: P06907, P25189, P27573
• Gene Symbols: MPZ
• Immunogen: Recombinant Human MPZ protein, Ile30-Lys248 (Accession #P25189).
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Pig
• Product Type: Antibody
• Isotype: IgG3 κ

• Applications: Western Blot, Immunohistochemistry (Paraffin), Western Blot
• Clone: C13
• Conjugate: Unconjugated
• Gene: MPZ
• Gene Alias: Charcot-Marie-Tooth neuropathy 1B; CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; CMTDID; DSS; HMSNIB; MPP; MPZ; Myelin peripheral protein; myelin protein P0; Myelin protein zero; myelin protein zero (Charcot-Marie-Tooth neuropathy 1B); P0; P-zero
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 100153273, 17528, 24564, 4359
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid