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Invitrogen™ MPZ Polyclonal Antibody
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Catalog No. PIPA572541
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400 μL
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Catalog No. Quantity
PIPA572541 400 μL
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Catalog No. PIPA572541 Supplier Invitrogen™ Supplier No. PA572541
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Description

Rabbit Polyclonal Antibody

MPZ Polyclonal Antibody for Western Blot, IHC (P), Flow

Zero, also known as myelin protein zero (MPZ) is a Type 1 integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath in order to ensure stable synaptic transmission. Zero protein encompasses approximately 50% of total protein in the sheath scaffolding in contribution to structural integrity of peripheral myelin. Zero guides the compact myelin wrapping process through glycine zipper packing interface-dependent dimer and tetramer formation. Mutations (e.g. G134R) can abrogate multimer formation, cause demyelinating neuropathies, and are known to contribute to conditions that include Charcot-Marie-Tooth disease. Zero cytoplasmic domain undergoes serine and tyrosine phosphorylation, which appears to be prevalent during peak nerve myelination. Zero transcript is moderate in brain, abundant in thymus and most abundant in white matter of the CNS.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MPZ
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.45 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene MPZ
Gene Accession No. P25189
Gene Alias Charcot-Marie-Tooth neuropathy 1B; CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; CMTDID; DSS; HMSNIB; MPP; MPZ; Myelin peripheral protein; myelin protein P0; Myelin protein zero; myelin protein zero (Charcot-Marie-Tooth neuropathy 1B); P0; P-zero
Gene Symbols MPZ
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide between 186-215 amino acids from the C-terminal region of human MPZ.
Purification Method Antigen affinity chromatography, Protein A
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4359
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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