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Invitrogen™ MPZ Recombinant Rabbit Monoclonal Antibody (3C4D1)
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Catalog No. FEMA551335
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100 μL
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FEMA551335 100 μL
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Catalog No. FEMA551335 Supplier Invitrogen™ Supplier No. MA551335
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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: KVPTRYGVVL GAVIGGVLGV VLLLLLLFYV VRYCWLRRQA ALQRRLSAME KGKLHKPGKD ASKRGRQTPV LYAMLDHSRS TKAVSEKKAK GLGESRKDKK.

Zero, also known as myelin protein zero (MPZ) is a Type 1 integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath in order to ensure stable synaptic transmission. Zero protein encompasses approximately 50% of total protein in the sheath scaffolding in contribution to structural integrity of peripheral myelin. Zero guides the compact myelin wrapping process through glycine zipper packing interface-dependent dimer and tetramer formation. Mutations (e.g. G134R) can abrogate multimer formation, cause demyelinating neuropathies, and are known to contribute to conditions that include Charcot-Marie-Tooth disease. Zero cytoplasmic domain undergoes serine and tyrosine phosphorylation, which appears to be prevalent during peak nerve myelination. Zero transcript is moderate in brain, abundant in thymus and most abundant in white matter of the CNS.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MPZ
Applications ELISA, Western Blot
Classification Recombinant Monoclonal
Clone 3C4D1
Concentration 1.18 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene MPZ
Gene Accession No. P06907, P27573
Gene Alias Charcot-Marie-Tooth neuropathy 1B; CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; CMTDID; DSS; HMSNIB; MPP; MPZ; Myelin peripheral protein; myelin protein P0; Myelin protein zero; myelin protein zero (Charcot-Marie-Tooth neuropathy 1B); P0; P-zero
Gene Symbols MPZ
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 149-248 of human Myelin Protein Zero (MPZ) (NP_000521.2).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17528, 24564
Target Species Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Format Liquid
Isotype IgG
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