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MRCKalpha Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501563233
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Catalog No. Quantity
50-156-3233 100 μL
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Catalog No. 50-156-3233 Supplier Bethyl Laboratories, Inc Supplier No. A302693A
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Mouse and Rat

MRCK alpha (myotonic dystrophy kinase-related Cdc42-binding kinase alpha) is a member of the dystrophia myotonica protein kinase (DMPK) family that functions downstream of Cdc42 in actin cytoskeletal reorganization. It is a serine/threonine kinase with multiple functional domains, including phorbol ester-responsive C1 domain. Three independent coiled-coil domains and the N-terminal region preceding the kinase domain are responsible for intermolecular interactions leading to MRCK alpha multimerization. The transautophosphorylation process is critical for regulation of MRCK alpha catalytic activities. Binding of phorbol esters to MRCK releases its autoinhibition, allowing N-terminal dimerization and subsequent kinase activation.

Specifications

Antigen MRCKalpha
Applications Immunoprecipitation
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene CDC42BPA
Gene Accession No. Q5VT25
Gene Alias RP5-1087E8.4, DKFZp686L1738, DKFZp686P1738, FLJ23347, KIAA0451, MRCK, MRCKA, PK428, CDC42 binidng protein kinase beta, CDC42-binding protein kinase alpha (DMPK-like), DMPK-like alpha, MRCK alpha, myotonic dystrophy kinase-related CDC42-binding kinase alpha, myotonic dystrophy kinase-related CDC42-binding protein kinase alpha, myotonic dystrophy protein kinase-like alpha, ser-thr protein kinase PK428, ser-thr protein kinase related to the myotonic dystrophy protein kinase, serine/threonine-protei
Gene Symbols CDC42BPA
Host Species Rabbit
Immunogen Between 1560 and 1610
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8476
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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