Invitrogen™ MREG Polyclonal Antibody

Catalog No.	Quantity
PIPA567001	100 μL

Catalog No. PIPA567001 Supplier Invitrogen™ Supplier No. PA567001

Description

Rabbit Polyclonal Antibody

Immunogen sequence: GLRDWLRTVCC CCGCECLEER ALPEKEPLVS DNNPYSSFGA TLVRDDEKNL WSMPHDVSHT EADDDRTLY Highest antigen sequence identity to the following orthologs - mouse 86%, rat 86%.

Probably functions as cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Plays a role in hair pigmentation, a process that involves shedding of melanosome-containing vesicles from melanocytes, followed by phagocytosis of the melanosome-containing vesicles by keratinocytes. Functions on melanosomes as receptor for RILP and the complex formed by RILP and DCTN1, and thereby contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate, but not phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 4,5-bisphosphate. Required for normal phagosome clearing and normal activation of lysosomal enzymes in lysosomes from retinal pigment epithelium cells (PubMed:19240024). Required for normal degradation of the lipofuscin component N-retinylidene-N-retinylethanolamine (A2E) in the eye. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells. [UniProt].

Specifications

• Antigen: MREG
• Applications: Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.9 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: MREG
• Gene Accession No.: Q8N565
• Gene Alias: dilute suppressor protein; Dilute suppressor protein homolog; Dsu; Gm974; HDCGA21P; Melanoregulin; MREG; RGD1562333; WDT2; Whn-dependent transcript 2
• Gene Symbols: MREG
• Host Species: Rabbit
• Immunogen: Recombinant Human MREG. Recombinant protein control fragment (Product #RP-107643).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 55686
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG