Invitrogen™ MRP5 Monoclonal Antibody (M5II-54)

Rat Monoclonal Antibody

Supplier:  Invitrogen™ MA135684

Catalog No. 01-671-090

Description

M5II-54 reacts with an internal epitope of MRP5, a 190-200 kD transmembrane protein that is closely related to the multidrug resistance protein MRP. M5II-54 was raised against a bacterial fusion protein of MRP5, containing amino acids 722-910 of the protein. M5I-1 does not cross-react with the human MDR1, MRP1, MRP2 or MRP3 gene products.

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.

Specifications

• Antigen: MRP5
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: Tissue culture supernatant with 0.7% BSA and 0.1% sodium azide
• Gene Accession No.: O15440
• Gene Symbols: ABCC5
• Immunogen: MRP5 aa 722-910.
• Regulatory Status: RUO
• Gene ID (Entrez): 10057
• Content And Storage: 4°C
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
• Clone: M5II-54
• Conjugate: Unconjugated
• Gene: ABCC5
• Gene Alias: 2900011L11Rik; ABC 33; ABC33; ABCC 5; ABCC5; Abcc5a; Abcc5b; AI132311; ATP binding cassette subfamily C member 5; ATP-binding cassette sub-family C (CFTR/MRP) member 5a; ATP-binding cassette sub-family C member 5; ATP-binding cassette, subfamily C (CFTR/MRP), member 5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5a; ATP-binding cassette, sub-family C (CFTR/MRP), member 5b; ATP-binding cassette, sub-family C, member 5; canalicular multispecific organic anion transporter C; DKFZp686C1782; EST277145; MOAT C; MOATC; MOAT-C; MRP 5; MRP5; multidrug resistance-associated protein 5; Multi-specific organic anion transporter C; pABC 11; pABC11; SMRP
• Host Species: Rat
• Quantity: 1 mL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a