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Invitrogen™ MRP5 Polyclonal Antibody
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Catalog No. PIPA5102678
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PIPA5102678 100 μL
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Catalog No. PIPA5102678 Supplier Invitrogen™ Supplier No. PA5102678
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total ABCC5.

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MRP5
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene ABCC5
Gene Accession No. O15440, Q9QYM0, Q9R1X5
Gene Alias 2900011L11Rik; ABC 33; ABC33; ABCC 5; ABCC5; Abcc5a; Abcc5b; AI132311; ATP binding cassette subfamily C member 5; ATP-binding cassette sub-family C (CFTR/MRP) member 5a; ATP-binding cassette sub-family C member 5; ATP-binding cassette, subfamily C (CFTR/MRP), member 5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5a; ATP-binding cassette, sub-family C (CFTR/MRP), member 5b; ATP-binding cassette, sub-family C, member 5; canalicular multispecific organic anion transporter C; DKFZp686C1782; EST277145; MOAT C; MOATC; MOAT-C; MRP 5; MRP5; multidrug resistance-associated protein 5; Multi-specific organic anion transporter C; pABC 11; pABC11; SMRP
Gene Symbols ABCC5
Host Species Rabbit
Immunogen A synthesized peptide derived from human ABCC5(Accession O15440), corresponding to amino acid residues M1-R33.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10057, 116721, 27416
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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