Invitrogen™ MRP5 Polyclonal Antibody

Catalog No.	Quantity
PIPA518965	100 μg

Catalog No. PIPA518965 Supplier Invitrogen™ Supplier No. PA518965

Description

Goat Polyclonal Antibody

This antibody is predicted to react with bovine, canine, mouse, porcine and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.

Specifications

• Antigen: MRP5
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene: ABCC5
• Gene Accession No.: O15440
• Gene Alias: 2900011L11Rik; ABC 33; ABC33; ABCC 5; ABCC5; Abcc5a; Abcc5b; AI132311; ATP binding cassette subfamily C member 5; ATP-binding cassette sub-family C (CFTR/MRP) member 5a; ATP-binding cassette sub-family C member 5; ATP-binding cassette, subfamily C (CFTR/MRP), member 5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5a; ATP-binding cassette, sub-family C (CFTR/MRP), member 5b; ATP-binding cassette, sub-family C, member 5; canalicular multispecific organic anion transporter C; DKFZp686C1782; EST277145; MOAT C; MOATC; MOAT-C; MRP 5; MRP5; multidrug resistance-associated protein 5; Multi-specific organic anion transporter C; pABC 11; pABC11; SMRP
• Gene Symbols: ABCC5
• Host Species: Goat
• Immunogen: Synthetic peptide sequence (KDIDIGKEYIIP) corresponding to the N-terminus amino acids of ABCC5 (aa 2-14).
• Purification Method: Ammonium sulfate precipitation
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10057
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG