Invitrogen™ MRP5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA550520

Catalog No. PA550520

Description

The antibody detects endogenous levels of total ABCC5 protein.

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.

Specifications

• Antigen: MRP5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ABCC5
• Gene Alias: 2900011L11Rik; ABC 33; ABC33; ABCC 5; ABCC5; Abcc5a; Abcc5b; AI132311; ATP binding cassette subfamily C member 5; ATP-binding cassette sub-family C (CFTR/MRP) member 5a; ATP-binding cassette sub-family C member 5; ATP-binding cassette, subfamily C (CFTR/MRP), member 5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5a; ATP-binding cassette, sub-family C (CFTR/MRP), member 5b; ATP-binding cassette, sub-family C, member 5; canalicular multispecific organic anion transporter C; DKFZp686C1782; EST277145; MOAT C; MOATC; MOAT-C; MRP 5; MRP5; multidrug resistance-associated protein 5; Multi-specific organic anion transporter C; pABC 11; pABC11; SMRP
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10057, 27416
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1.9 mg/mL
• Formulation: PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: O15440, Q9R1X5
• Gene Symbols: ABCC5
• Immunogen: Synthetic peptide corresponding to residues near the N terminal of human ATP-binding cassette, sub-family C.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG