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Invitrogen™ MRP6 Monoclonal Antibody (M6II-31)
Rat Monoclonal Antibody
Supplier: Invitrogen™ MA135687
Description
M6II-31 reacts with MRP6, a 190-200 kD transmembrane protein that is related to the multidrug resistance related protein MRP. Mutations in the MRP6 gene are responsible for the connective tissue disorder Pseudoxanthoma elasticum (PXE). M6II-31 was raised against a bacterial fusion protein of human MRP6, containing amino acids 764-964, spanning the putative 12th transmembrane region as well as predicted internal and external regions of the protein. M6II-31 did not cross-react with the human MDR1, MRP1, MRP2, MRP3, MRP4, MRP5 gene products.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene.
Specifications
MRP6 | |
Monoclonal | |
Conc. Not Determined | |
tissue culture supernatant with 0.7% BSA and 0.1% sodium azide | |
O95255 | |
ABCC6 | |
ABCC6 aa 764-964. | |
RUO | |
368 | |
4°C | |
Liquid |
Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
M6II-31 | |
Unconjugated | |
ABCC6 | |
ABC34; Abcc1b; ABCC6; Anthracycline resistance-associated protein; ARA; ATP binding cassette subfamily C member 6; ATP-binding cassette sub-family C member 6; ATP-binding cassette, subfamily C (CFTR/MRP), member 6; ATP-binding cassette, sub-family C (CFTR/MRP), member 6; ATP-binding cassette, sub-family C, member 6; DCC; dyscalc; Dyscalc1; EST349056; GACI2; liver multidrug resistance-associated protein 6; Mlp1; MLP-1; MOATE; MOAT-E; Mrp6; MRP-like protein 1; Multidrug resistance-associated protein 6; multidrug resistance-associated protein-6; multi-specific organic anion transporter E; PXE; PXE1; URG7; URG7 protein; multidrug resistance-associated protein 6 | |
Rat | |
1 mL | |
Primary | |
Human | |
Antibody | |
IgG2a |
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