Invitrogen™ MRPL12 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA554621

Catalog No. PIPA554621

Description

Immunogen sequence: VMSGAVPAAA AQEAVEEDIP IAKERTHFTV RLTEAKPVDK VKLIKEIKNY IQGINLVQAK KLVESLPQEI KANVAKAEAE KIKAALEAVG GTVVLE Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 86%.

MRPL12 (mitochondrial ribosomal protein L12), also referred to as 5c5-2, L12mt, MRPL7 or RPML12, is a mammalian mitochondrial ribosomal protein that is involved in protein synthesis within the mitochondrion. MRPL12 is enhanced in growth-stimulated cells as a result of transcriptional activation, suggesting that it may function as a translational regulator of mitochondrial mRNAs. Impairment of MRPL12 leads to reduction in cell growth rate, decreased mitochondrial ATP production and abolition of mitochondrial oxidative phosphorylation. MRPL12 is cleaved during its translocation across the mitochondrial membrane and it exists as dimers that bind the large ribosomal subunit. MRPL12 is 198 amino acids in length, belongs to the ribosomal protein L12P family and is highly expressed in the colon.

Specifications

• Antigen: MRPL12
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MRPL12
• Gene Alias: 0610034O11Rik; 1500031N16Rik; 39S ribosomal protein L12, mitochondrial; 5c5-2; FLJ60124; hypothetical protein LOC550391; im:6893415; L12mt; MGC8610; Mitochondrial large ribosomal subunit protein bL12m; mitochondrial ribosomal protein L12; mitochondrial ribosomal protein L7/12; MRPL12; MRP-L12; MRP-L31/34; MRPL7; MRPL7/L12; ribosomal protein, mitochondrial, L12; Rpm12; RPML12; zgc:112445
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6182
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P52815
• Gene Symbols: MRPL12
• Immunogen: Recombinant protein corresponding to Human MRPL12. Recombinant protein control fragment (Product #RP-93518).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov