Invitrogen™ MRPL40 Polyclonal Antibody

Catalog No.	Quantity
PIPA552265	100 μL

Catalog No. PIPA552265 Supplier Invitrogen™ Supplier No. PA552265

Description

Rabbit Polyclonal Antibody

Immunogen sequence: TQLRETQELI PIEDFITPLK FLDKARERPQ VELTFEETER RALLLKKWSL YKQQERKMER DTIRAMLEAQ QEALEELQLE SPKLHAEAIK RDPNLFPFEK EGPHYTPPIP NYQPPEGRYN DITK Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 77%.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Deletions in this gene may contribute to the etiology of velo-cardio-facial syndrome and DiGeorge syndrome.

Specifications

• Antigen: MRPL40
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: MRPL40
• Gene Accession No.: P83565, Q9NQ50, Q9Z2Q5
• Gene Alias: 39S ribosomal protein L40, mitochondrial; L40mt; Mitochondrial large ribosomal subunit protein mL40; mitochondrial ribosomal protein L40; MRPL22; MRP-L22; Mrpl40; MRP-L40; Nlvcf; nuclear localization signal protein absent in velo-cardio-facial patients; nuclear localization signal-containing protein deleted in velocardiofacial syndrome; Nuclear localization signal-containing protein deleted in velocardiofacial syndrome homolog; up-regulated in metastasis; URIM
• Gene Symbols: MRPL40
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human MRPL40. Recombinant protein control fragment (Product #RP-91336).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 18100, 287962, 64976
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG