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Invitrogen™ MRPS12 Polyclonal Antibody
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Catalog No. PIPA5101345
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PIPA5101345 100 μL
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Catalog No. PIPA5101345 Supplier Invitrogen™ Supplier No. PA5101345
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total MRPS12.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene; all three variants encode the same protein.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MRPS12
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene MRPS12
Gene Accession No. O15235, O35680
Gene Alias 28S ribosomal protein S12, mitochondrial; AI327385; mitochondrial ribosomal protein S12; Mitochondrial small ribosomal subunit protein uS12m; mitoribosomal protein s12; MPR-S12; Mrps12; MRP-S12; MT-RPS12; ribosomal protein, mitochondrial, S12; RPMS12; RPS12; RPSM12; S12mt; Unknown (protein for MGC:137645)
Gene Symbols MRPS12
Host Species Rabbit
Immunogen A synthesized peptide derived from human MRPS12(Accession O15235), corresponding to amino acid residues P51-T101.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 24030, 6183
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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