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Invitrogen™ MRPS12 Polyclonal Antibody
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Catalog No. PIPA5120096
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100 μL
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PIPA5120096 100 μL
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Catalog No. PIPA5120096 Supplier Invitrogen™ Supplier No. PA5120096
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Description

Rabbit Polyclonal Antibody

Positive test controls include: LO2, U-251MG, HT-29, 293T. The target is usually found in the following locations: Mitochondrion. Immunogen sequence: MATLNQMHRL GPPKRPPRKL GPTEGRPQLK GVVLCTFTRK PKKPNSANRK CCRVRLSTGR EAVCFIPGEG HTLQEHQIVL VEGGRTQDLP GVKLTVVRGK YDCGHVQKK.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene; all three variants encode the same protein.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MRPS12
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.82 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene MRPS12
Gene Accession No. O15235
Gene Alias 28S ribosomal protein S12, mitochondrial; AI327385; mitochondrial ribosomal protein S12; Mitochondrial small ribosomal subunit protein uS12m; mitoribosomal protein s12; MPR-S12; Mrps12; MRP-S12; MT-RPS12; ribosomal protein, mitochondrial, S12; RPMS12; RPS12; RPSM12; S12mt; Unknown (protein for MGC:137645)
Gene Symbols MRPS12
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 30-138 of human MRPS12 (NP_203527.1).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6183
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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