Tocris™ MRT 67307 dihydrochloride

Salt inducible kinase (SIK) inhibitor

Manufacturer: Tocris™ 5134/10

 View more versions of this product

Catalog No. 51-341-0

  Check Availability
Add to Cart

Disclaimers:

For Research Use Only


    Specifications

    Product Type MRT 67307 dihydrochloride
    Inhibitors MRT 67307 dihydrochloride
    Purity >98
    Molecular Weight 537.52
    Quantity 10mg

    Salt inducible kinase (SIK) inhibitor (IC50 values are 67, 250 and 430nM for SIK2, SIK1 and SIK3 respectively). Also inhibits TBK1, MARK1-4, IKKε and NUAK1 (IC50 values are 19, 27-52, 160 and 230nM respectively). Has no effect on IKKα or IKKβ. Induces IL-10 secretion and inhibits TNF-α and IL-6 secretion in bacterial LPS-stimulated macrophages. Also enhances IL-1-induced activation of NFκB-dependent gene transcription in mouse embryonic fibroblast (MEF) cells.

    • Chemical Name: N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide dihydrochloride
    • Formula: C26H36N6O2.2HCl
    • Solubility: Soluble to 20mM in water and to 100mM in DMSO
    • Purity: >98

  • Description & Specifications

Related Products


Product Content Feedback

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit