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  5. Tocris Bioscience™ MRTX 849

Tocris Bioscience™ MRTX 849
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Catalog No. 748850
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Quantity:
10 mg
50 mg
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Description

Mutation-selective inhibitor of KRASG12C

MRTX 849 is a mutant-selective inhibitor of KRASG12C (IC50 = 142 nM). MRTX 849 covalently binds to KRASG12C at the cysteine at residue 12 and inhibits KRAS-dependent signal transduction by locking the protein in its inactive GDP-bound state. MRTX 849 induces pronounced tumor regression in 17 of 26 (65%) KRASG12C -positive cell lines and patient-derived xenograft models from multiple tumor types. It is orally bioavailable.

Specifications

Chemical Name or Material 4-[7-(8-Chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2 S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-(2 S)-2-piperazineacetonitrile
CAS 2326521-71-3
Quantity 50 mg
Target Ras GTPase Inhibitors
Molecular Formula C32H35ClFN7O2
Purity 98%
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