Invitrogen™ MRVI1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552592

Catalog No. PIPA552592

Description

Immunogen sequence: NLVGLKLPDL SEAAEQEKGL PSELSPAIEE EESKSGLDVM PNISDVLLRK LRVHRSLPGS APPLTEKEVE NVFVQLSLAF RNDSYTLESR INQAERERNL Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 90%.

This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during lymphoid differentiation. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, few of which initiate translation at a non-AUG (CUG) start site.

Specifications

• Antigen: MRVI1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MRVI1
• Gene Alias: BB115629; inositol 1,4,5-triphosphate receptor associated 1; inositol 1,4,5-triphosphate receptor associated 1; protein MRVI1; inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate; inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate; IP3 receptor associated cGMP kinase substrate; IP3 receptor associated cGMP kinase substrate A; IP3 receptor associated cGMP kinase substrate B; IP3R-associated cGMP kinase substrate; IRAG; IRAG1; JAW1L; JAW1-related protein MRVI1; MRV integration site 1; MRVI1; murine retrovirus integration site 1 homolog; murine retrovirus integration site 1 protein; Protein MRVI1; retroviral integration site 1; Ris1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10335
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9Y6F6
• Gene Symbols: MRVI1
• Immunogen: Recombinant protein corresponding to Human MRVI1. Recombinant protein control fragment (Product #RP-89975).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG