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Tocris Bioscience™ MS 143

Catalog No. 80815
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5 mg
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80-815 5 mg
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Catalog No. 80-815 Supplier Tocris Bioscience™ Supplier No. 8081/5
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Description

AKT kinase Degrader (PROTAC™)

MS 143 is a potent and selective protein kinase B (AKT) Degrader (PROTAC™) (DC50 = 46 nM, Dmax = 100 % at 24h in PC3 cells). MS 143 suppresses growth in prostate cancer PC3 cells; suppresses tumor growth and reduces AKT protein levels in a mouse PC3 cell xenograft model.

PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

Chemical Name or Material 4-Amino-N-((S)-1-(4-chlorophenyl)-3-(4-(12-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-12-oxododecanoyl)piperazin-1-yl)propyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4
CAS 2376137-41-4
Quantity 5 mg
Target Active Degraders
Molecular Formula C59H81ClN12O6S
Purity 97%
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