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Tocris Bioscience™ MS 147
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Catalog No. 80772
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2 mg
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80-772 2 mg
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Catalog No. 80-772 Supplier Tocris Bioscience™ Supplier No. 8077/2
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Description

PRC1 Degrader (PROTAC™); degrades BMI1 and RING1B

MS 147 is a polycomb repressive complex 1 (PRC1) Degrader (PROTAC™) (Kd values are 450 nM and 3 μM for VHL and EED, respectively). Comprises an EED binder ( EED 226, Cat. No. 7762) joined by a linker to a VHL E3 ligase ligand. MS 147 preferentially degrades BMI1 and RING1B and reduces H2AK119ub in K562 cells. Inhibits proliferation in cancer cell lines that are insensitive to EZH2 knockout or EED/PRC2 Degraders.

Specifications

Chemical Name or Material (2S,4R)-1-((S)-2-(7-(5-(4-(4-(5-((Furan-2-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)phenyl)piperazin-1-yl)pentanamido)heptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
Quantity 2 mg
Target Active Degraders
Molecular Formula C54H70N12O6S.xHCl
Purity 0.97
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