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R&D Systems™ MS 41
SDP

Catalog No. RD10188035 Shop All Novus Products
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RD10188035 5 mg
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Catalog No. RD10188035 Supplier R&D Systems™ Supplier No. 8919/5

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Description

A Tocris product, part of R&D Systems.

MS 41 is a potent and selective Eleven-Nineteen Leukemia (ENL) Degrader (PROTAC™) (DC50 = 2.84 nM, 3.03 nM, 3.50 nM and 26.58 nM in SEMK2, Jurkat, MV4;11 and KASUMI1 cells, respectively). Comprises an ENL-binding moiety (PFI-6) joined by a linker to VHL1-Me as the ligand for von Hippel-Lindau E3 ubiquitin ligase. MS41 effectively inhibits leukemia cell proliferation and clonogenic ability in vitro and suppresses leukemia progression in a xenograft mouse model of MLL-r leukemia in vivo.

PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license

Specifications

Chemical Name or Material 5-[4-(Dimethylcarbamoyl)-3-hydroxyphenyl]-N-[(1R)-6-[[10-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-10-oxodecyl]carbamoyl]-2,3-dihydro-1H-inden-1-yl]-1,2
CAS 2768610-97-3
Quantity 5 mg
Product Line Tocris
Target PROTACs (Proteolysis Targeting Chimeras)
Molecular Formula C56H70N8O9S
Purity 97%
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