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Tocris Bioscience™ MS 4322

Catalog No. 80802
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2 mg
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80-802 2 mg
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Catalog No. 80-802 Supplier Tocris Bioscience™ Supplier No. 8080/2
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Description

Selective PRMT5 Degrader (PROTAC™)

MS 4322 is a protein arginine methyltransferase 5 (PRMT5) Degrader (PROTAC™) (DC50 = 1.1 μM, Dmax = 74% in MCF-7 cells). Also inhibits PRMT5 methyltransferase activity (IC50 = 18 nM) and dose-dependently inhibits proliferation of HeLa, A549, A172 and Jurkat cancer cell lines. Comprises a PRMT5 inhibitor linked to an E3 ligase ligand.

PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

Chemical Name or Material N-((S)-3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-((1-((S)-19-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidine-1-carbonyl)-20,20-dimethyl-17-oxo-3,6,9,12,15-pentaoxa-18-azahenicosanoyl)azetidin-3-yl)amin
CAS 2375432-47-4
Quantity 2 mg
Target Active Degraders
Molecular Formula C55H76N10O12S
Purity 98%
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