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  6. Epredia™ Lab Vision™ MSH2 (Mismatch Repair Protein 2) Ab-1, Mouse Monoclonal Antibody

Epredia™ Lab Vision™ MSH2 (Mismatch Repair Protein 2) Ab-1, Mouse Monoclonal Antibody

Catalog No. MS1498RQ Shop All Epredia Products
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12 mL
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Catalog No. Quantity Form
MS1498RQ 12 mL Ready-to-Use
MS1498S0 100 μL Concentrated
MS1498S1 500 μL Concentrated
MS1498S 1 mL Concentrated
MS1498R1 1 mL Prediluted
MS1498R7 7 mL Prediluted
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Catalog No. MS1498RQ Supplier Epredia™ Supplier No. MS1498RQ

Description

Choose one marker in a comprehensive antibody portfolio that addresses all major disease states, ensuring the ideal tests are always available.

Germline mutations in human mismatch repair genes (hMSH2, hMSH6, hMLH1, hPMS2) account for majority of the hereditary non-polyposis colorectal carcinoma (HPNCC). CpG dinucleotides in the hMSH2 and hMLH1 genes are hotspots for HNPCC mutations. These mutations cause a mismatch repair deficiency resulting in a mutator phenotype where the replication errors are not repaired. Microsatellites/simple repeatative sequences are prone to this type of replication errors and instability of these microsatellites correlates with the occurance of HPNCC. hMSH2 binds to another MutS homolog protein GTBP to form a heterodimeric complex called hMutSβ, which binds to insertion/deletion loops in DNA.

Host Species: Mouse

Clone: 25D12

Isotype: IgG1/κ

Species Reactivity: Human. Others not tested.

Immunogen: Recombinant human MSH2 protein

Molecular Weight: ∽102kDa

Positive Control: Tonsil

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)

Specifications

Antigen MSH2 (Mismatch Repair Protein 2) Ab-1
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 25D12
Conjugate Unconjugated
Host Species Mouse
Immunogen Recombinant human MSH2 protein
Quantity 12 mL
Regulatory Status IVD
Research Discipline DNA Repair
Primary or Secondary Primary
Form Ready-to-Use
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