Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. Epredia™ Lab Vision™ MSH2 (Mismatch Repair Protein 2) Ab-1, Mouse Monoclonal Antibody

Epredia™ Lab Vision™ MSH2 (Mismatch Repair Protein 2) Ab-1, Mouse Monoclonal Antibody

Catalog No. MS1498S0 Shop All Epredia Products
Change view
Click to view available options
Quantity:
100 μL
500 μL
1 mL
7 mL
12 mL
Form:
Concentrated
Prediluted
Ready-to-Use
6 product options available for selection
Product selection table with 6 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity Form
MS1498S0 100 μL Concentrated
MS1498S1 500 μL Concentrated
MS1498S 1 mL Concentrated
MS1498R1 1 mL Prediluted
MS1498R7 7 mL Prediluted
MS1498RQ 12 mL Ready-to-Use
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 6 options available.
6 options
Catalog No. MS1498S0 Supplier Epredia™ Supplier No. MS1498S0

Description

Choose one marker in a comprehensive antibody portfolio that addresses all major disease states, ensuring the ideal tests are always available.

Germline mutations in human mismatch repair genes (hMSH2, hMSH6, hMLH1, hPMS2) account for majority of the hereditary non-polyposis colorectal carcinoma (HPNCC). CpG dinucleotides in the hMSH2 and hMLH1 genes are hotspots for HNPCC mutations. These mutations cause a mismatch repair deficiency resulting in a mutator phenotype where the replication errors are not repaired. Microsatellites/simple repeatative sequences are prone to this type of replication errors and instability of these microsatellites correlates with the occurance of HPNCC. hMSH2 binds to another MutS homolog protein GTBP to form a heterodimeric complex called hMutSβ, which binds to insertion/deletion loops in DNA.

Host Species: Mouse

Clone: 25D12

Isotype: IgG1/κ

Species Reactivity: Human. Others not tested.

Immunogen: Recombinant human MSH2 protein

Molecular Weight: ∽102kDa

Positive Control: Tonsil

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)

Specifications

Antigen MSH2 (Mismatch Repair Protein 2) Ab-1
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 25D12
Conjugate Unconjugated
Host Species Mouse
Immunogen Recombinant human MSH2 protein
Quantity 100 μL
Regulatory Status IVD
Research Discipline DNA Repair
Primary or Secondary Primary
Target Species Human
Form Concentrated
Isotype IgG2a κ
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.