Invitrogen™ MSH3 Recombinant Rabbit Monoclonal Antibody (RM405)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA536071

Catalog No. PIMA536071

Description

MSH3 Recombinant Monoclonal Antibody for Western Blot, IHC (P)

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.

Specifications

• Antigen: MSH3
• Classification: Recombinant Monoclonal
• Concentration: 0.04 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
• Gene Accession No.: P20585
• Gene Symbols: MSH3
• Immunogen: A peptide corresponding to residues near the N-terminus of human MSH3.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: RM405
• Conjugate: Unconjugated
• Gene: MSH3
• Gene Alias: D13Em1; Divergent upstream protein; DNA mismatch repair protein Msh3; DUC1; DUG; DUP; hMSH3; Mismatch repair protein 1; MRP1; MSH3; mutS homolog 3; mutS homolog 3 (E. coli); protein repair-1; Protein repair-3; REP-1; Rep3; Rep-3
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 4437
• Content And Storage: -20°C
• Form: Liquid