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Invitrogen™ MSH3 Polyclonal Antibody
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Catalog No. PIPA527864
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100 μL
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PIPA527864 100 μL
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Catalog No. PIPA527864 Supplier Invitrogen™ Supplier No. PA527864
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: A549, H1299, HCT116. Predicted reactivity: Rat (81%), Bovine (83%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MSH3
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.01% thimerosal; pH 7
Gene MSH3
Gene Accession No. P20585
Gene Alias D13Em1; Divergent upstream protein; DNA mismatch repair protein Msh3; DUC1; DUG; DUP; hMSH3; Mismatch repair protein 1; MRP1; MSH3; mutS homolog 3; mutS homolog 3 (E. coli); protein repair-1; Protein repair-3; REP-1; Rep3; Rep-3
Gene Symbols MSH3
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the N-terminus region of human MSH3. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4437
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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