Invitrogen™ MSI2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA531024

Catalog No. PIPA531024

Description

Recommended positive controls: IMR32, MCF-7, mouse brain. Predicted reactivity: Mouse (100%), Xenopus laevis (97%), Bovine (84%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Msi2 (musashi homolog 2), also known as MSI2H, is a 328 amino acid protein that localizes to the cytoplasm and contains two RRM (RNA recognition motif) domains. Expressed ubiquitously at low levels, Msi2 functions as an RNA binding protein that, by regulating the expression of target mRNAs, is thought to play a role in the proliferation and maintenance of stem cells within the central nervous system. Msi2 is subject to posttranslational phosphorylation and is upregulated in response to brain injury, suggesting a role in healing and brain tissue regeneration. Chromosomal aberrations involving the Msi2 gene are associated with the progression of chronic myeloid leukemia. Multiple isoforms of Msi2 exist due to alternative splicing events.Tissue specificity: Ubiquitous; detected at low levels.

Specifications

• Antigen: MSI2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MSI2
• Gene Alias: 1700105C15Rik; AI451722; AI563628; AW489193; MSI2; Msi2h; musashi homolog 2; musashi RNA binding protein 2; musashi RNA-binding protein 2; Musashi2; musashi-2; RGD1560397; RNA-binding protein Musashi homolog 2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 124540, 360596, 76626
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q920Q6, Q96DH6
• Gene Symbols: MSI2
• Immunogen: Recombinant protein encompassing a sequence within the center region of human Musashi 2. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG