Invitrogen™ MSL2 Monoclonal Antibody (3A4)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA522114

Catalog No. PIMA522114

Description

Peptide Sequence: GQRCPCYSNR KACLDCICRG CQNSYMANGE KKLEAFAVPE KALEQTRLTL GINVTSIAVR NASTSTSVIN VTGSPVTTFL AASTHDDKSL DEAIDMRF.

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. [UniProt].

Specifications

• Antigen: MSL2
• Classification: Monoclonal
• Concentration: 0.2-1.0 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: Q9HCI7
• Gene Symbols: MSL2
• Immunogen: MSL2 (NP_060603, 478 a.a. ~ 575 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: ELISA
• Clone: 3A4
• Conjugate: Unconjugated
• Gene: MSL2
• Gene Alias: E130103E02Rik; E3 ubiquitin-protein ligase MSL2; E3 ubiquitin-protein transferase MSL2; Kiaa1585; male-specific lethal 2 homolog; male-specific lethal 2 homolog (Drosophila); male-specific lethal 2-like 1; Male-specific lethal-2 homolog; Male-specific lethal-2 homolog 1; MSL2; MSL-2; Msl2l1; MSL2-like 1; RGD1310355; ring finger protein 184; Rnf184
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55167
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid