MSL2 Monoclonal Antibody (OTI3G5), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA811223

Catalog No. 50-168-3916

Description

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at ′Lys-35′ (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at ′Lys-4′ (H3K4me) and ′Lys-79′ (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.

Specifications

• Antigen: MSL2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q9HCI7
• Gene Symbols: MSL2
• Immunogen: Full length human recombit protein of human MSL2 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI3G5
• Conjugate: Unconjugated
• Gene: MSL2
• Gene Alias: MSL-2, MSL2L1, RNF184
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55167
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid