Invitrogen™ MSL2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA565518

Catalog No. PIPA565518

Description

Immunogen sequence: DKAVKEKIPSH HFMPGSPTKT VYKKPQEKKG CKCGRATQNP SVLTCRGQRC PCYSNRKACL DCICRGCQNS YMANGEKKLE AFAVPEKALE QTRLTLGINV TSIAVRNAST STSVINVTGS PVTTFLAAST HDDKSLDEAI Highest antigen sequence identity to the following orthologs - mouse 99%, rat 100%.

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. [UniProt].

Specifications

• Antigen: MSL2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MSL2
• Gene Alias: E130103E02Rik; E3 ubiquitin-protein ligase MSL2; E3 ubiquitin-protein transferase MSL2; Kiaa1585; male-specific lethal 2 homolog; male-specific lethal 2 homolog (Drosophila); male-specific lethal 2-like 1; Male-specific lethal-2 homolog; Male-specific lethal-2 homolog 1; MSL2; MSL-2; Msl2l1; MSL2-like 1; RGD1310355; ring finger protein 184; Rnf184
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55167
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9HCI7
• Gene Symbols: MSL2
• Immunogen: Recombinant Human MSL2. Recombinant protein control fragment (Product #RP-104856).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG