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MSR1 Mouse anti-Human, Clone: OTI2B5, lyophilized, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner CF802779

Catalog No. 50-166-6157


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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

CD204 gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer ft.s disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a domit negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.
Specifications

Specifications

MSR1
Monoclonal
Unconjugated
MSR1
Lyophilized
MSR1
Human recombit protein fragment corresponding to amino acids 197-451 of human MSR1 produced in E.coli.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Western Blot
OTI2B5
PBS with 8% trehalose and no preservative; pH 7.3
P21757
CD204, SCARA1, SR-A, SR-AI, SR-AII, SR-AIII, SRA, phSR1, phSR2
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
4481
SDS
Documents
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