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MSR1 Mouse anti-Human, Clone: OTI5F9, lyophilized, TrueMAB™

Mouse Monoclonal Antibody
Supplier: OriGene CF802782

Description
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO
CD204 gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer′s disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a domit negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.Specifications
MSR1 | |
Monoclonal | |
Unconjugated | |
MSR1 | |
CD204, SCARA1, SR-A, SR-AI, SR-AII, SR-AIII, SRA, phSR1, phSR2 | |
Mouse | |
Affinity Chromatography | |
RUO | |
4481 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
Western Blot | |
OTI5F9 | |
PBS with 8% trehalose and no preservative; pH 7.3 | |
P21757 | |
MSR1 | |
Human recombit protein fragment corresponding to amino acids 197-451 of human MSR1 produced in E.coli. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG1 |
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