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MSR1 Mouse anti-Human, Clone: OTI8B11, lyophilized, TrueMAB™
SDP

Catalog No. 501666186
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100 μg
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50-166-6186 100 μg
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Catalog No. 50-166-6186 Supplier OriGene Supplier No. CF802828
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Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

CD204 gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer′s disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a domit negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.

Specifications

Antigen MSR1
Applications Western Blot
Classification Monoclonal
Clone OTI8B11
Conjugate Unconjugated
Formulation PBS with 8% trehalose and no preservative; pH 7.3
Gene MSR1
Gene Accession No. P21757
Gene Alias CD204, SCARA1, SR-A, SR-AI, SR-AII, SR-AIII, SRA, phSR1, phSR2
Gene Symbols MSR1
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 197-451 of human MSR1 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4481
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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