MSS1 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-6343	100 μL

Catalog No. 50-198-6343 Supplier Bioss Supplier No. BS5120R

Description

Rabbit Polyclonal Antibody

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (˜31), barrel-shaped molecular machine with an apparent molecular weight of ˜2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

Specifications

• Antigen: MSS1
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: PSMC2
• Gene Accession No.: P35998
• Gene Alias: 26S protease regulatory subunit 7; 26S proteasome AAA-ATPase subunit RPT1; 26S proteasome regulatory subunit 7; mammalian suppressor of sgv-1 of yeast; MGC3004; Mss1; Nbla10058; protease 26S subunit 7; proteasome (prosome, macropain) 26S subunit, ATPase 2; proteasome (prosome, macropain) 26S subunit, ATPase, 2; Proteasome 26S subunit ATPase 2; proteasome 26S subunit, ATPase 2; proteasome 26S subunit, ATPase, 2; Protein MSS1; Psmc2; putative protein product of Nbla10058; S7; testis secretory sperm-binding protein Li 197a
• Gene Symbols: PSMC2
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human MSS1.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5701
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG