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MST1 Mouse anti-Human, Clone: OTI4B12, lyophilized, TrueMAB™
SDP

Catalog No. 501668806
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100 μg
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50-166-8806 100 μg
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Catalog No. 50-166-8806 Supplier OriGene Supplier No. CF808369
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Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

MST1 is a stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.

Specifications

Antigen MST1
Applications Western Blot
Classification Monoclonal
Clone OTI4B12
Conjugate Unconjugated
Formulation PBS with 8% trehalose and no preservative; pH 7.3
Gene MST1
Gene Accession No. P26927
Gene Alias D3F15S2, DNF15S2, HGFL, MSP, NF15S2
Gene Symbols MST1
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 194-462 of human MST1 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4485
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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