DescriptionMST2 (mammalian sterile twenty-like 2; also known as STK3 and Krs-1) is a 58kDa member of the GCKII group of the STE20 subfamily of the STE Ser/Thr kinase protein family. In human, MST2 is 491 amino acids (aa) in length. It contains one kinase domain (aa 27-278), two NESs (aa 361-371 and 438-447) and coiled-coil domains (aa 287-328 and 442-475), and one NLS (aa 473-487). A caspase-cleavage site exists between Asp322-Ser323. MST2 is normally inactive in the cytoplasm bound to Raf-1. Cell activation induces Raf-1:MST2 dissociation, MST2 cleavage, and N-terminal translocation to the nucleus. Human MST2 is 99% and 96% aa identical to canine and mouse MST2, respectively.
|Immunocytochemistry, Immunohistochemistry, Western Blot|
|Protein A or G purified from hybridoma culture supernatant|
|Supplied as a solution in PBS containing BSA, Glycerol and Sodium Azide. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS. with Sodium Azide|
|Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.|
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