MST2 Rabbit anti-Human, Zebrafish, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA572649

Catalog No. PIPA572649

Description

Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein stk3/mst2 and stk4/mst1, in complex with its regulatory protein sav1, phosphorylates and activates lats1/2 in complex with its regulatory protein mob1, which in turn phosphorylates and inactivates yap1 oncoprotein and wwtr1/taz. Phosphorylation of yap1 by lats2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (By similarity).

Specifications

• Antigen: MST2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: STK3
• Gene Alias: Serine/threonine-protein kinase 3; Serine/threonine-protein kinase 3 36kDa subunit; MST2/N; Serine/threonine-protein kinase 3 20kDa subunit; MST2/C; stk3
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 324125, 6788
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: Q13188, Q7ZUQ3
• Gene Symbols: STK3
• Immunogen: KLH conjugated synthetic peptide between 228-252 amino acids from the Central region of zebrafish MST2
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Zebrafish
• Product Type: Antibody
• Isotype: IgG