Invitrogen™ Complex I Monoclonal Antibody (18G12BC2)

Catalog No.	Quantity
43-880-0	100 μg

Catalog No. 43-880-0 Supplier Invitrogen™ Supplier No. 438800

Description

Mouse Monoclonal Antibody

Positive control: fibroblasts, HL-60 cells, tissue mitochondria.

Complex I, or NADH ubiquinone oxidoreductase, is a large protein complex of 950,000 Da molecular weight made up by 45 to 46 different subunits. A total of seven of the subunits of the complex are encoded by mitochondrial DNA, while the remainder subunits are nuclear encoded, which are translated in the cytosol and translocated into the organelle for assembly at the inner membrane. The enzyme complex catalyses electron entry from NADH via a flavin (FMN) and several non-heme iron centers. Complex I is sensitive to a wide range of inhibitors, many of which are pesticides or other common environmental toxins, such as rotenone. Complex I dysfunction is a common cause of genetic OXPHOS defects. Altered functioning of this complex is also thought to contribute to several neurological disorders including Parkinson's disease and schizophrenia. Also, there is evidence of Complex I involvement in diabetes.

Specifications

• Antigen: Complex I
• Applications: Flow Cytometry, Immunoprecipitation, Immunocytochemistry
• Classification: Monoclonal
• Clone: 18G12BC2
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: HEPES buffered saline with 0.02% sodium azide
• Gene: NDUFAB1
• Gene Accession No.: A4FUH5, O00217, O00483, O08776, O09111, O14561, O15239, O35683, O43181, O43674, O43676, O43677, O43678, O43920, O75251, O75306, O75380, O75438, O75489, O95139, O95167, O95168, O95169, O95178, O95182, O95298, O95299, O96000, O97725, P03886, P03887, P03888, P03889, P03891, P03897, P03899, P03901, P03905, P03911, P03915, P03923, P03925, P04394, P05506, P05508, P0DN34, P0DN35, P11661, P15690, P17568, P17694, P19234, P19404, P23709, P23934, P23935, P25708, P25712, P28331, P34942, P34943, P42026, P42028, P42029, P48305, P49821, P51970, P52503, P52504, P52505, P56181, P56556, Q01321, Q02365, Q02366, Q02367, Q02368, Q02369, Q02370, Q02371, Q02372, Q02373, Q02374, Q02375, Q02376, Q02377, Q02378, Q02379, Q02380, Q02827, Q05752, Q16718, Q16795, Q2HJI2, Q32P65, Q3SZ44, Q3UIU2, Q4FZG9, Q59J78, Q5BK63, Q5XIF3, Q62425, Q63362, Q641Y2, Q66HF1, Q6PCU8, Q7TMF3, Q80W89, Q86Y39, Q8BK30, Q8HXG5, Q8HXG6, Q8K3J1, Q8N183, Q91VD9, Q91WD5, Q91YT0, Q95KV7, Q99LC3, Q99LY9, Q9BU61, Q9CPP6, Q9CPU2, Q9CQ54, Q9CQ75, Q9CQ91, Q9CQC7, Q9CQH3, Q9CQJ8, Q9CQY9, Q9CQZ5, Q9CQZ6, Q9CR21, Q9CR61, Q9CWX2, Q9CXZ1, Q9D1H6, Q9D6J5, Q9D6J6, Q9D8B4, Q9DC69, Q9DC70, Q9DCJ5, Q9DCS9, Q9DCT2, Q9ERS2, Q9JKL4, Q9NQR8, Q9NRX3, Q9NX14, Q9P032, Q9P0J0, Q9UI09, Q9Y375, Q9Y6M9, Q9Z1P6
• Gene Alias: 0610006N12Rik; 0610007D05Rik; 0610010M09Rik; 0610011B04Rik; 0610033L03Rik; 1010001M04Rik; 1010001M12Rik; 1010001N11Rik; 1110002H15Rik; 1110007M04Rik; 1190008J14Rik; 13 kDa differentiation-associated protein; 1300010H20Rik; 13kDa differentiation-associated protein; 14.5b subunit of the NADH-ubiquinone dehydrogenase complex; 14.5kDa; 14kDa; 1500032D16Rik; 16 kDa precursor; 1700022J01Rik; 1810004I06Rik; 1810011O01Rik; 1810049F12Rik; 1810058I14Rik; 19 kDa; 19 kDa subunit of NADH:ubiquinone oxidoreductase complex (complex I); 2010012C24Rik; 2010300P09Rik; 2210401F17Rik; 22kDa; 2310016K22Rik; 2310039H15Rik; 2400007M02Rik; 2410001M24Rik; 2410011G03Rik; 24-kDa subunit of mitochondrial NADH dehydrogenase; 2610003B19Rik; 2700033I16Rik; 2700038D15Rik; 2700054G14Rik; 2900002J19Rik; 2900010C23Rik; 2900010I05Rik; 2900053E13Rik; 2P1; 3000003G13Rik; 4733401H18Rik; 5830412M15Rik; 6720411N02Rik; 8kDa; 9130423F15Rik; 9930026A05Rik; Aa2-258; ACP; Acyl carrier protein, mitochondrial; AGGG; AI256693; AI325567; AI415450; AI987932; AL033311; AQDQ; ASHI; AU015782; AU022060; AV000592; AV006275; AW112974; AW214064; AW261656; B12; B13; B14; B14.5a; B14.5b; B14.7; B15; B15 subunit of the NADH: ubiquinone oxidoreductase complex; B16.6; B17; B17.2; B17.2L; B17.2-like; B18; B22; B230217P19Rik; B8; B9; bA22L21.1; BC021616; BC059730; BC064011; C1-18k; C1-B8; C22H3orf60; C3orf60; C6orf66; C86051; C9H6ORF66; CC6; CD14; CDA016; Cell adhesion protein SQM1; cell death regulatory protein GRIM-19; cell death-regulatory protein GRIM19; CGI-39; CGI65; CGI-65; CI; CI-10k; CI-13kA; CI-13kB; CI13KDA; CI-13kD-A; CI-13KD-B; CI-15 kDa; CI15K; CI-15k; CI-18; CI-18 kDa; CI-19kD; CI-20; CI-20KD; CI-23k; CI23KD; CI-23kD; CI-24k; CI-30; CI-30kD; CI39k; CI-39k; CI-39kD; CI-42k; CI-42kD; CI-49; CI-49kD; CI-51K; CI51KD; CI-51kD; CI-75k; CI-75Kd; CI-9k; CI-9KD; CIA30; CI-AGGG; CI-AQDQ; CI-ASHI; CI-B12; CI-B14; CI-B14.5a; CI-B14.5b; CI-B14.7; CI-B14-5A; CI-B15; CI-B16.6; CI-B17; CIB17.2; CI-B17.2; CI-B18; CI-B22; CIB8; CI-B8; CI-B9; CI-ESSS; CI-KFYI; CI-MLRQ; CI-MNLL; CI-MWFE; CI-PDSW; CI-PGIV; CI-SDAP; CISGDH; CI-SGDH; complex 1, mitochondrial respiratory chain, 49-KD subunit; complex I 10kDa subunit; complex I 13kDa subunit A; complex I 13kDa subunit B; complex I 18kDa subunit; complex I 20kDa subunit; complex I 23kDa subunit; complex I 24kDa subunit; complex I 30kDa subunit; complex I 39kDa subunit; complex I 42kDa subunit; complex I 49kDa subunit; complex I 51 kda subunit; complex I 51kDa subunit; complex I 75kDa subunit; Complex I 9kDa subunit; complex I AGGG subunit; complex I ASHI subunit; complex I B14 subunit; complex I B14.5a subunit; complex I B14.7 subunit; complex I B15 subunit; complex I B16.6 subunit; complex I B17.2 subunit; complex I B18 subunit; complex I B22 subunit; complex I B8 subunit; complex I B9 subunit; complex I intermediate-associated protein 30, mitochondrial; complex I KFYI subunit; complex I MNLL subunit; complex I MWFE subunit; complex I NP17.3 subunit; complex I PDSW subunit; complex I SDAP subunit; complex I SGDH subunit; complex I subunit B13; complex I subunit B14.5b; complex I, mitochondrial respiratory chain; complex I, mitochondrial respiratory chain, 10-kD subunit; complex I, mitochondrial respiratory chain, 13-kD subunit; complex I, mitochondrial respiratory chain, 20-KD subunit; complex I, mitochondrial respiratory chain, 75-kD subunit; complex I, mitochondrial respiratory chain, B17 subunit; complex I, mitochondrial respitory chain, 24 kD subunit; complex I-13kD-A; Complex I-13kD-B; complex I-15 kDa; Complex I-18 kDa; complex I-19kD; Complex I-20kD; complex I-23kD; Complex I-30kD; complex I-39kD; Complex I-42kD; complex I-49kD; Complex I-51kD; complex I-75kD; Complex I-9kD; complex I-AGGG; Complex I-AQDQ; complex I-ASHI; Complex I-B12; complex I-B14; Complex I-B14.5a; complex I-B14.5b; Complex I-B14.7; complex I-B15; Complex I-B16.6; complex I-B17; Complex I-B17.2; complex I-B18; Complex I-B22; complex I-B8; Complex I-B9; complex I-ESSS
• Gene Symbols: MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, ND1, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFAF1, NDUFAF2, NDUFAF3, NDUFAF4, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3
• Host Species: Mouse
• Immunogen: Bovine Heart Complex I.
• Purification Method: IgG fraction
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 0, 100362331, 100911483, 100912357, 104130, 110324555, 126328, 17716, 17718, 17719, 17722, 17991, 17992, 17993, 17995, 225887, 226646, 227197, 230075, 25488, 25915, 26193, 26199, 26201, 26202, 281742, 282289, 282290, 282517, 287014, 287027, 287327, 288088, 288380, 289218, 29078, 291660, 293130, 293453, 293652, 293655, 293991, 29478, 294964, 295923, 296086, 296658, 297990, 299310, 299643, 299739, 299954, 301123, 301427, 301458, 315167, 326346, 327660, 327665, 327670, 327673, 327680, 327690, 327691, 327697, 327698, 327701, 327702, 327704, 327706, 327710, 327713, 327714, 327717, 3283877, 338046, 338057, 338060, 338061, 338063, 338064, 338065, 338073, 338079, 338084, 361385, 361894, 362344, 362440, 362495, 362588, 362837, 363441, 374291, 404161, 404188, 407785, 407790, 4535, 4536, 4537, 4538, 4539, 4540, 4541, 4694, 4695, 4696, 4697, 4698, 4700, 4701, 4702, 4704, 4705, 4706, 4707, 4708, 4709, 4710, 4711, 4712, 4713, 4714, 4715, 4716, 4717, 4718, 4719, 4720, 4722, 4723, 4724, 4725, 4726, 4728, 4729, 4731, 499529, 51079, 51103, 511968, 541232, 54405, 54539, 55967, 56769, 56901, 595136, 613541, 615440, 64539, 66046, 66091, 66108, 66218, 66377, 66414, 66416, 66495, 66706, 66916, 67130, 67184, 67264, 67273, 678759, 681024, 681418, 68194, 68197, 68198, 68202, 68342, 68349, 68375, 68493, 689938, 691001, 69702, 69875, 70316, 72900, 75406, 75597, 767961, 78330, 81728, 91942
• Target Species: Human, Mouse, Rat, Bovine
• Content And Storage: 4°C, do not freeze
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b κ