Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Invitrogen™ Complex I Monoclonal Antibody (18G12BC2)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ 438800

Encompass_Preferred

Catalog No. 43-880-0


Only null left
Add to Cart

Description

Description

Positive control: fibroblasts, HL-60 cells, tissue mitochondria.

Complex I, or NADH ubiquinone oxidoreductase, is a large protein complex of 950,000 Da molecular weight made up by 45 to 46 different subunits. A total of seven of the subunits of the complex are encoded by mitochondrial DNA, while the remainder subunits are nuclear encoded, which are translated in the cytosol and translocated into the organelle for assembly at the inner membrane. The enzyme complex catalyses electron entry from NADH via a flavin (FMN) and several non-heme iron centers. Complex I is sensitive to a wide range of inhibitors, many of which are pesticides or other common environmental toxins, such as rotenone. Complex I dysfunction is a common cause of genetic OXPHOS defects. Altered functioning of this complex is also thought to contribute to several neurological disorders including Parkinson's disease and schizophrenia. Also, there is evidence of Complex I involvement in diabetes.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Complex I
Monoclonal
1 mg/mL
HEPES buffered saline with 0.02% sodium azide
A4FUH5, O00217, O00483, O08776, O09111, O14561, O15239, O35683, O43181, O43674, O43676, O43677, O43678, O43920, O75251, O75306, O75380, O75438, O75489, O95139, O95167, O95168, O95169, O95178, O95182, O95298, O95299, O96000, O97725, P03886, P03887, P03888, P03889, P03891, P03897, P03899, P03901, P03905, P03911, P03915, P03923, P03925, P04394, P05506, P05508, P0DN34, P0DN35, P11661, P15690, P17568, P17694, P19234, P19404, P23709, P23934, P23935, P25708, P25712, P28331, P34942, P34943, P42026, P42028, P42029, P48305, P49821, P51970, P52503, P52504, P52505, P56181, P56556, Q01321, Q02365, Q02366, Q02367, Q02368, Q02369, Q02370, Q02371, Q02372, Q02373, Q02374, Q02375, Q02376, Q02377, Q02378, Q02379, Q02380, Q02827, Q05752, Q16718, Q16795, Q2HJI2, Q32P65, Q3SZ44, Q3UIU2, Q4FZG9, Q59J78, Q5BK63, Q5XIF3, Q62425, Q63362, Q641Y2, Q66HF1, Q6PCU8, Q7TMF3, Q80W89, Q86Y39, Q8BK30, Q8HXG5, Q8HXG6, Q8K3J1, Q8N183, Q91VD9, Q91WD5, Q91YT0, Q95KV7, Q99LC3, Q99LY9, Q9BU61, Q9CPP6, Q9CPU2, Q9CQ54, Q9CQ75, Q9CQ91, Q9CQC7, Q9CQH3, Q9CQJ8, Q9CQY9, Q9CQZ5, Q9CQZ6, Q9CR21, Q9CR61, Q9CWX2, Q9CXZ1, Q9D1H6, Q9D6J5, Q9D6J6, Q9D8B4, Q9DC69, Q9DC70, Q9DCJ5, Q9DCS9, Q9DCT2, Q9ERS2, Q9JKL4, Q9NQR8, Q9NRX3, Q9NX14, Q9P032, Q9P0J0, Q9UI09, Q9Y375, Q9Y6M9, Q9Z1P6
MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, ND1, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFAF1, NDUFAF2, NDUFAF3, NDUFAF4, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3
Bovine Heart Complex I.
100 μg
Primary
Human, Mouse, Rat, Bovine
Antibody
IgG2b κ
Flow Cytometry, Immunoprecipitation, Immunocytochemistry
18G12BC2
Unconjugated
NDUFV2
0610006N12Rik; 0610007D05Rik; 0610010M09Rik; 0610011B04Rik; 0610033L03Rik; 1010001M04Rik; 1010001M12Rik; 1010001N11Rik; 1110002H15Rik; 1110007M04Rik; 1190008J14Rik; 13 kDa differentiation-associated protein; 1300010H20Rik; 13kDa differentiation-associated protein; 14.5b subunit of the NADH-ubiquinone dehydrogenase complex; 14.5kDa; 14kDa; 1500032D16Rik; 16 kDa precursor; 1700022J01Rik; 1810004I06Rik; 1810011O01Rik; 1810049F12Rik; 1810058I14Rik; 19 kDa; 19 kDa subunit of NADH:ubiquinone oxidoreductase complex (complex I); 2010012C24Rik; 2010300P09Rik; 2210401F17Rik; 22kDa; 2310016K22Rik; 2310039H15Rik; 2400007M02Rik; 2410001M24Rik; 2410011G03Rik; 24-kDa subunit of mitochondrial NADH dehydrogenase; 2610003B19Rik; 2700033I16Rik; 2700038D15Rik; 2700054G14Rik; 2900002J19Rik; 2900010C23Rik; 2900010I05Rik; 2900053E13Rik; 2P1; 3000003G13Rik; 4733401H18Rik; 5830412M15Rik; 6720411N02Rik; 8kDa; 9130423F15Rik; 9930026A05Rik; Aa2-258; ACP; Acyl carrier protein, mitochondrial; AGGG; AI256693; AI325567; AI415450; AI987932; AL033311; AQDQ; ASHI; AU015782; AU022060; AV000592; AV006275; AW112974; AW214064; AW261656; B12; B13; B14; B14.5a; B14.5b; B14.7; B15; B15 subunit of the NADH: ubiquinone oxidoreductase complex; B16.6; B17; B17.2; B17.2L; B17.2-like; B18; B22; B230217P19Rik; B8; B9; bA22L21.1; BC021616; BC059730; BC064011; C1-18k; C1-B8; C22H3orf60; C3orf60; C6orf66; C86051; C9H6ORF66; CC6; CD14; CDA016; Cell adhesion protein SQM1; cell death regulatory protein GRIM-19; cell death-regulatory protein GRIM19; CGI-39; CGI65; CGI-65; CI; CI-10k; CI-13kA; CI-13kB; CI13KDA; CI-13kD-A; CI-13KD-B; CI-15 kDa; CI15K; CI-15k; CI-18; CI-18 kDa; CI-19kD; CI-20; CI-20KD; CI-23k; CI23KD; CI-23kD; CI-24k; CI-30; CI-30kD; CI39k; CI-39k; CI-39kD; CI-42k; CI-42kD; CI-49; CI-49kD; CI-51K; CI51KD; CI-51kD; CI-75k; CI-75Kd; CI-9k; CI-9KD; CIA30; CI-AGGG; CI-AQDQ; CI-ASHI; CI-B12; CI-B14; CI-B14.5a; CI-B14.5b; CI-B14.7; CI-B14-5A; CI-B15; CI-B16.6; CI-B17; CIB17.2; CI-B17.2; CI-B18; CI-B22; CIB8; CI-B8; CI-B9; CI-ESSS; CI-KFYI; CI-MLRQ; CI-MNLL; CI-MWFE; CI-PDSW; CI-PGIV; CI-SDAP; CISGDH; CI-SGDH; complex 1, mitochondrial respiratory chain, 49-KD subunit; complex I 10kDa subunit; complex I 13kDa subunit A; complex I 13kDa subunit B; complex I 18kDa subunit; complex I 20kDa subunit; complex I 23kDa subunit; complex I 24kDa subunit; complex I 30kDa subunit; complex I 39kDa subunit; complex I 42kDa subunit; complex I 49kDa subunit; complex I 51 kda subunit; complex I 51kDa subunit; complex I 75kDa subunit; Complex I 9kDa subunit; complex I AGGG subunit; complex I ASHI subunit; complex I B14 subunit; complex I B14.5a subunit; complex I B14.7 subunit; complex I B15 subunit; complex I B16.6 subunit; complex I B17.2 subunit; complex I B18 subunit; complex I B22 subunit; complex I B8 subunit; complex I B9 subunit; complex I intermediate-associated protein 30, mitochondrial; complex I KFYI subunit; complex I MNLL subunit; complex I MWFE subunit; complex I NP17.3 subunit; complex I PDSW subunit; complex I SDAP subunit; complex I SGDH subunit; complex I subunit B13; complex I subunit B14.5b; complex I, mitochondrial respiratory chain; complex I, mitochondrial respiratory chain, 10-kD subunit; complex I, mitochondrial respiratory chain, 13-kD subunit; complex I, mitochondrial respiratory chain, 20-KD subunit; complex I, mitochondrial respiratory chain, 75-kD subunit; complex I, mitochondrial respiratory chain, B17 subunit; complex I, mitochondrial respitory chain, 24 kD subunit; complex I-13kD-A; Complex I-13kD-B; complex I-15 kDa; Complex I-18 kDa; complex I-19kD; Complex I-20kD; complex I-23kD; Complex I-30kD; complex I-39kD; Complex I-42kD; complex I-49kD; Complex I-51kD; complex I-75kD; Complex I-9kD; complex I-AGGG; Complex I-AQDQ; complex I-ASHI; Complex I-B12; complex I-B14; Complex I-B14.5a; complex I-B14.5b; Complex I-B14.7; complex I-B15; Complex I-B16.6; complex I-B17; Complex I-B17.2; complex I-B18; Complex I-B22; complex I-B8; Complex I-B9; complex I-ESSS
Mouse
IgG fraction
RUO
0, 100362331, 100911483, 100912357, 104130, 110324555, 126328, 17716, 17718, 17719, 17722, 17991, 17992, 17993, 17995, 225887, 226646, 227197, 230075, 25488, 25915, 26193, 26199, 26201, 26202, 281742, 282289, 282290, 282517, 287014, 287027, 287327, 288088, 288380, 289218, 29078, 291660, 293130, 293453, 293652, 293655, 293991, 29478, 294964, 295923, 296086, 296658, 297990, 299310, 299643, 299739, 299954, 301123, 301427, 301458, 315167, 326346, 327660, 327665, 327670, 327673, 327680, 327690, 327691, 327697, 327698, 327701, 327702, 327704, 327706, 327710, 327713, 327714, 327717, 3283877, 338046, 338057, 338060, 338061, 338063, 338064, 338065, 338073, 338079, 338084, 361385, 361894, 362344, 362440, 362495, 362588, 362837, 363441, 374291, 404161, 404188, 407785, 407790, 4535, 4536, 4537, 4538, 4539, 4540, 4541, 4694, 4695, 4696, 4697, 4698, 4700, 4701, 4702, 4704, 4705, 4706, 4707, 4708, 4709, 4710, 4711, 4712, 4713, 4714, 4715, 4716, 4717, 4718, 4719, 4720, 4722, 4723, 4724, 4725, 4726, 4728, 4729, 4731, 499529, 51079, 51103, 511968, 541232, 54405, 54539, 55967, 56769, 56901, 595136, 613541, 615440, 64539, 66046, 66091, 66108, 66218, 66377, 66414, 66416, 66495, 66706, 66916, 67130, 67184, 67264, 67273, 678759, 681024, 681418, 68194, 68197, 68198, 68202, 68342, 68349, 68375, 68493, 689938, 691001, 69702, 69875, 70316, 72900, 75406, 75597, 767961, 78330, 81728, 91942
4°C, do not freeze
Liquid
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Product Certifications
Promotions

Promotions

Product Content Correction

The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.