Invitrogen™ MT-ND2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120600

Catalog No. PIPA5120600

Description

Positive test controls include: Mouse brain, Rat brain. Immunogen sequence: LLSLGGLPPL TGFLPKWAII EEFTKNNSLI IPTIMATITL LNLYFYLRLI YSTSITLLPM SNNVKMKWQF EHTKPTPFLP TLIALTTLLL PISPFMLMIL.

MT-ND2: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Defects in MT-ND2 are a cause of Leber hereditary optic neuropathy (LHON). LHON is a maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes. Defects in MT-ND2 may be associated with susceptibility to Alzheimer disease mitochondrial (AD-MT).

Specifications

• Antigen: MT-ND2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MT-ND2
• Gene Alias: mitochondrially encoded NADH dehydrogenase 2; Mtnd2; mt-Nd2; NADH dehydrogenase subunit 2; NADH2; NADH-ubiquinone oxidoreductase chain 2; ND2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 17717, 26194, 4536
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.72 mg/mL
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene Accession No.: P03891, P03893, P11662
• Gene Symbols: MT-ND2, ND2
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 248-347 of human MT-ND2 (YP_0030240271).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG