Invitrogen™ MT-ND3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103274

Catalog No. PIPA5103274

Description

Antibody detects endogenous levels of total MT-ND3.

NADH:ubiquinone oxidoreductase (complex I) is an extremely complicated multiprotein complex located in the inner mitochondrial membrane. Human complex I is important for energy metabolism because its main function is to transport electrons from NADH to ubiquinone, which is accompanied by trans-location of protons from the mitochondrial matrix to the intermembrane space. Human complex I appears to consist of 41 subunits. A small number of complex I subunits are the products of mitochondrial genes (subunits 1-7), while the remainder are nuclear encoded and imported from the cytoplasm. NADH dehydrogenase subunit 3 (ND3) localizes to the hydrophobic protein fragment of complex I. Mutations in the gene encodiing for ND3 may be associated with Parkinson disease.

Specifications

• Antigen: MT-ND3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MT-ND3
• Gene Alias: 1.6.5.3; mitochondrially encoded NADH dehydrogenase 3; Mtnd3; mt-Nd3; NADH dehydrogenase subunit 3; NADH3; NADH-ubiquinone oxidoreductase chain 3; ND3
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 17718, 26199, 4537
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P03897, P03899, P05506
• Gene Symbols: MT-ND3
• Immunogen: A synthesized peptide derived from human MT-ND3(Accession P03897), corresponding to amino acid residues L15-F65.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov