Invitrogen™ MT-ND4L Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103953

Catalog No. PIPA5103953

Description

Antibody detects endogenous levels of total MT-ND4L.

NADH:ubiquinone oxidoreductase (complex I) is an extremely complicated multiprotein complex located in the inner mitochondrial membrane. Human complex I is important for energy metabolism because its main function is to transport electrons from NADH to ubiquinone, which is accompanied by translocation of protons from the mitochondrial matrix to the intermembrane space. Human complex I appears to consist of 41 subunits. A small number of complex I subunits are the products of mitochondrial genes (subunits 1-7), while the remainder are nuclear encoded and imported from the cytoplasm. NADH dehydrogenase subunit 4L (ND4L) is most likely a component of the hydrophobic protein fragment of Complex I. Mutations in the gene encodiing for ND4 are implicated in Leber hereditary optic neuropathy, a rare condition that can cause loss of central vision.

Specifications

• Antigen: MT-ND4L
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MT-ND4L
• Gene Alias: mitochondrially encoded NADH 4L dehydrogenase; MTND4L; mt-Nd4l; NADH dehydrogenase subunit 4L; NADH4L; NADH-ubiquinone oxidoreductase chain 4L; Nd4l
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 17720, 4539
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P03901, P03903
• Gene Symbols: MT-ND4L, ND4L
• Immunogen: A synthesized peptide derived from human MT-ND4L(Accession P03901), corresponding to amino acid residues M1-L49.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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