Invitrogen™ MTA1 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA131417

Catalog No. PIPA131417

Description

Recommended positive controls: The peptide used to generate this antibody is available for purchase (GTX20751-PEP).. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling.

Specifications

• Antigen: MTA1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MTA1
• Gene Alias: metastasis associated 1; metastasis associated gene 1 protein; metastasis-associated protein MTA1; MTA1; Zg29
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9112
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q13330
• Gene Symbols: MTA1
• Immunogen: synthetic peptide PGDVFYMPKE (Human).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov