Invitrogen™ MTA2 Polyclonal Antibody

Catalog No.	Quantity
PIPA582239	100 μL

Catalog No. PIPA582239 Supplier Invitrogen™ Supplier No. PA582239

Description

Rabbit Polyclonal Antibody

Immunogen sequence: ECSIRLPKAA KTPLKIHPLV RLPLATIVKD LVAQAPLKPK TPRGTKTPIN RNQLSQNRGL GGIMVKRAYE TMAGAGVPFS ANGRPLASGI RSSSQPAAKR QKLNPADAPN PVVFVATKDT RALRKALTHL EMRRAARRPN LPLKVKPT Highest antigen sequence indentity to the following orthologs: Mouse - 99%, Rat - 96%.

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.

Specifications

• Antigen: MTA2
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: Mta2
• Gene Accession No.: O94776, Q9R190
• Gene Alias: AW550797; DKFZp686F2281; Mata1l1; metastais-associated gene family, member 2; metastasis associated 1 family member 2; metastasis associated 1 family, member 2; metastasis associated 1-like 1; metastasis -associated gene 1-like 1; metastasis associated gene family, member 2; metastasis-associated 1-like 1; metastasis-associated gene family, member 2; metastasis-associated protein 2; metastasis-associated protein MTA2; mmta2; Mta1l1; MTA1-L1 protein; Mta2; p53 target protein in deacetylase complex; PID
• Gene Symbols: Mta2
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human MTA2. Recombinant protein control fragment (Product #RP-89363).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 23942, 361724, 9219
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG