Invitrogen™ MTBP Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA588497

Catalog No. PIPA588497

Description

Immunogen sequence: MDRYLLLVIW GEGKFPSAAS REAEHGPEVS SGEGTENQPD FTAANVYHLL KRSISASINP EDSTFPACSV GGIPGSKKWF FAVQAIYGFY QFCSSDWQEI HFDTEKDKIE DVLQTNIEEC LGAVECFEEE DSNSRESLSL ADLYEEAAEN LHQLSDKLPA PGRAMVDIIL LLSDKDPPKL KDYLPTVGAL KHLREWYSAK ITIAGNHCEI NCQKIAEYLS ANVVSLEDLR NVIDSKELWR GKIQIWERKF GFEISFPEFC LKGVTLKNFS TSNLNTDFLA KKIIPSKDKN ILPKVFHYYG; Positive Samples: Mouse spleen.

MTBP inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. The protein may play a role in MDM2-dependent TP53/p53 homeostasis in unstressed cells. The protein inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of TP53/p53 and its subsequent degradation.

Specifications

• Antigen: MTBP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Mtbp
• Gene Alias: AI429604; hdm2; HDMX; hMTBP; MDM2 (mouse double minute 2)-binding protein, 104kD; MDM2 binding protein; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein binding protein, 104kDa; Mdm2, transformed 3T3 cell double minute p53 binding protein; mdm2-binding protein; MDM2BP; MGC5370; MGC71221; mMTBP; Mtbp; RGD1565672
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 105837
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q8BJS8
• Gene Symbols: Mtbp
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human MTBP (NP_0713282).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov