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Invitrogen™ MTF2 Polyclonal Antibody
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Catalog No. PIPA596571
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100 μL
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PIPA596571 100 μL
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Catalog No. PIPA596571 Supplier Invitrogen™ Supplier No. PA596571
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MRDSTGAGNS LVHKRSPLRR NQKTPTSLTK LSLQDGHKAK KPACKFEEGQ DVLARWSDGL FYLGTIKKIN ILKQSCFIIF EDSSKSWVLW KDIQTGATGS GEMVCTICQE EYSEAPNEMV ICDKCGQGYH QLCHTPHIDS SVIDSDEKWL CRQCVFATTT KRGGALKKGP NAKALQVMKQ TLPYSVADLE; Positive Samples: HL-60, HepG2, Mouse brain, Rat brain; Cellular Location: Nucleus.

Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MTF2
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.24 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Mtf2
Gene Accession No. Q02395, Q9Y483
Gene Alias 9230112N11Rik; AA537621; C76717; dJ976O13.2; hPCl2; M96; Metal regulatory transcription factor 2; metal response element binding transcription factor 2; metal response element DNA-binding protein M96; metal response element-binding transcription factor 2; metal-response element DNA-binding protein M96; Metal-response element-binding transcription factor 2; mPCl2; MTF2; PCL2; polycomb-like 2; polycomb-like protein 2; putative DNA binding protein; RGD1304727; RP5-976O13.1; TDRD19A; tudor domain containing 19A; zinc-regulated factor 1; ZiRF1
Gene Symbols Mtf2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human MTF2 (NP_0011578641).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17765, 22823, 360905
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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