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Invitrogen™ MTF2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA535931

Catalog No. PIPA535931


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Description

Description

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. Predicted reactivity: Mouse (95%), Rat (95%), Chicken (92%), Bovine (100%).

Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

MTF2
Polyclonal
Unconjugated
Mtf2
9230112N11Rik; AA537621; C76717; dJ976O13.2; hPCl2; M96; Metal regulatory transcription factor 2; metal response element binding transcription factor 2; metal response element DNA-binding protein M96; metal response element-binding transcription factor 2; metal-response element DNA-binding protein M96; Metal-response element-binding transcription factor 2; mPCl2; MTF2; PCL2; polycomb-like 2; polycomb-like protein 2; putative DNA binding protein; RGD1304727; RP5-976O13.1; TDRD19A; tudor domain containing 19A; zinc-regulated factor 1; ZiRF1
Rabbit
Antigen affinity chromatography
RUO
17765, 22823
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Immunocytochemistry
1 mg/mL
PBS with 20% glycerol and 0.01% thimerosal; pH 7
Q02395, Q9Y483
Mtf2
Recombinant fragment corresponding to a region within amino acids 401 and 593 of MTF2.
100 μL
Primary
Human, Mouse
Antibody
IgG
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