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Invitrogen™ MTM1 Polyclonal Antibody
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Catalog No. PIPA589279
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100 μL
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PIPA589279 100 μL
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Catalog No. PIPA589279 Supplier Invitrogen™ Supplier No. PA589279
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SARERQKVTE RTVSLWSLIN SNKEKFKNPF YTKEINRVLY PVASMRHLEL WVNYYIRWNP RIKQQQPNPV EQRYMELLAL RDEYIKRLEE LQLANSAKLS DPPTSPSSPS QMMPHVQTHF; Positive Samples: Mouse thymus; Cellular Location: Cell membrane, Cell projection, Cytoplasm, Late endosome, Peripheral membrane protein, filopodium, ruffle.

Human MTM1, a 603 amino-acid protein, is mutated in myotubular myopathy. The largely related protein hMTMR2 is found mutated in a recessive form of Charcot-Marie-tooth neuropathy. Myotubularin is primarily a lipid phosphatase that acts on hosphatidylinositol 3-monophosphate and is involved in the regulation of the phosphatidylinositol 3-kinase (PI 3-kinase) pathway and membrane trafficking. Wildtype myotubularin can directly dephosphorylate PI 3-P and PI 4-P in vitro. Thus, it decreases PI 3-P levels by down-regulating PI 3-K activity and by facilitating the degradation of PI 3-P.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MTM1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.14 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene MTM1
Gene Accession No. Q6AXQ4, Q9Z2C5
Gene Alias AF073996; CG2; CNM; fb19c01; hypothetical protein LOC560881; im:6903724; mKIAA4176; Mtm; MTM1; MTMX; myotubularin; myotubularin 1; Myotubularin-like protein; phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3-phosphate phosphatase; wu:fb19c01; X-linked myotubular myopathy gene 1; XLMTM; zgc:123266
Gene Symbols MTM1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 484-603 of human MTM1 (NP_0002431).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17772, 288762
Target Species Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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