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MTM1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 139241AP150UL

Encompass_Preferred

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Catalog No. 50-172-9095


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Description

Description

Human MTM1, a 603 amino-acid protein, is mutated in myotubular myopathy. The largely related protein hMTMR2 is found mutated in a recessive form of Charcot-Marie-tooth neuropathy. Myotubularin is primarily a lipid phosphatase that acts on hosphatidylinositol 3-monophosphate and is involved in the regulation of the phosphatidylinositol 3-kinase (PI 3-kinase) pathway and membrane trafficking. Wildtype myotubularin can directly dephosphorylate PI 3-P and PI 4-P in vitro. Thus, it decreases PI 3-P levels by down-regulating PI 3-K activity and by facilitating the degradation of PI 3-P.
Specifications

Specifications

MTM1
Polyclonal
Unconjugated
MTM1
CG2, CNM, MTM1, MTMX, Myotubularin, myotubularin 1, XLMTM
Rabbit
Antigen Affinity Chromatography
RUO
17772, 288762, 4534
-20°C
Liquid
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
0.35 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q13496, Q6AXQ4, Q9Z2C5
Mtm1
MTM1 Fusion Protein Ag4940
150 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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