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Invitrogen™ MTMR6 Polyclonal Antibody
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Catalog No. PIPA570556
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100 μL
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PIPA570556 100 μL
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Catalog No. PIPA570556 Supplier Invitrogen™ Supplier No. PA570556
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Description

Rabbit Polyclonal Antibody

This target displays homology in the following species: Dog: 93%; Guinea Pig: 86%; Horse: 86%; Human: 100%; Rabbit: 86%; Rat: 79%.

Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:19038970, PubMed:22647598). Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,5-bisphosphate (PubMed:19038970, PubMed:22647598) (Probable). Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (PubMed:19038970). Negatively regulates ER-Golgi protein transport. Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate (PubMed:15831468). Negatively regulates proliferation of reactivated CD4(+) T-cells (PubMed:16847315). In complex with MTMR9, negatively regulates DNA damage-induced apoptosis (PubMed:19038970, PubMed:22647598). The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen MTMR6
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene MTMR6
Gene Accession No. Q9Y217
Gene Alias 4022440C11Rik; AI428804; AU041072; MTMR6; myotubularin related protein 6; Myotubularin-like protein 6-like protein; myotubularin-related protein 6; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3-phosphate phosphatase
Gene Symbols MTMR6
Host Species Rabbit
Immunogen synthetic peptide directed towards the middle region of human MTMR6 (aa 531-580).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9107
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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